DCAF11-dependent molecular glue degrader activated by glutathionylation

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10873-1

M12 is a metabolically activated molecular glue that recruits diverse proteins to DCAF11 for ubiquitin-mediated degradation, revealing a glutathione-dependent mechanism that broadens targeted protein degradation across multiple substrates.